Evaluation of procalcitonin for the prediction of bacteremia
10.3969/j.issn.1673-4130.2014.12.015
- VernacularTitle:降钙素原在菌血症中的预测价值研究
- Author:
Jianfang LI
- Publication Type:Journal Article
- Keywords:
blood culture;
bacteremia;
procalcitonin;
ROC curve
- From:
International Journal of Laboratory Medicine
2014;(12):1557-1559
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of procalcitonin (PCT)in bacteremia.Methods Clinical data of adult pa-tients with suspected bacteremia were retrospectively analyzed for white blood cell counts(WBC),neutrophil absolute (NEU)and PCT levels in blood samples collected at the first time of blood culture.Receiver operating characteristic (ROC)curve was used to evaluate the values of different indexes for the prediction of bacteremia.Results A total of 120 patients were enrolled,including 47 patients (39.2%)with bacteremia and 73 patients (60.8%)without bacteremia.PCT,WBC and NEU levels were significantly higher in bacteremia patients than patients without bacteremia (P<0.01).Area under ROC curve of PCT was 0.836 (95%CI:0.767-0.904),which was significantly higher than WBC (0.676,95%CI:0.676-0.600)and NEU (0.696,95% CI:0.696-0.617).While area under ROC curve of WBC and NEU were no significantly different (P>0.05).Taking 0.43 ng/mL as cutoff value,the negative predictive value of PCT was 94.7%.The best cutoff value of PCT was 2.27 ng/mL,which was associated with sensitivity of 74.47%,specificity of 90.00%,positive predictive value of 83.3% and negative predictive value of 84.0%.Conclusion PCT might be with more clinical value for the prediction of bacteremi than WBC and NEU.
