The Classification between IgE and Non-IgE Mediated Atopic Dermatitis in Korean Children.
- Author:
Ju Suk LEE
1
;
Tae Hong KIM
;
Gyung Lae CHO
;
Jin A JUNG
;
Ja Hyeung KIM
Author Information
1. Department of Pediatrics, Sungkyunkwan University School of Medicine, Masan, South Korea. ljs8952194@lycos.co.k
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
Immunoglobulin E;
Immediate hypersensitivity
- MeSH:
Allergens;
Asthma;
Child*;
Classification*;
Dermatitis, Atopic*;
Dermatophagoides farinae;
Dermatophagoides pteronyssinus;
Diagnosis;
Egg White;
Eosinophils;
Female;
Humans;
Hypersensitivity, Immediate;
Immunoglobulin E*;
Milk;
Rhinitis;
Skin Diseases;
Soybeans
- From:Pediatric Allergy and Respiratory Disease
2005;15(4):352-358
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Atopic Dermatitis (AD) is a chronically relapsing inflammatory skin disease. Generally, aeroallergens and food allergens can exacerbate symptoms in AD. Currently they are divided into two groups: one is an IgE mediated form and the other is a non-IgE mediated form. This study focused upon clinical manifestations of two distinct forms of AD. METHODS: We evaluated 110 patients (male: 58, female: 52) with AD. All patients had visited Masan Samsung Hospital from June 2002 to February 2005. The patients were divided into 2 sub-groups according to their serum total IgE and specific IgE levels. The serum total IgE and specific IgE to Dermatophagoides pteronyssinus, Dermatophagoides farinae, Egg white, Cow's milk and Soybean were measured by the Pharmacia CAP-FEIA system. Metacholine provocation tests were conducted to reveal bronchial hyper-responsiveness and ARIA guidelines for diagnosis of AR were applied. RESULTS: Our study showed more female predominance in non IgE-mediated atopic dermatitis patients and showed higher total eosinophil count in IgE-mediated atopic dermatitis. (P< 0.05) There was no difference in frequency of asthma between two groups (P> 0.05), but allergic rhinitis was significantly predominant in non IgE-mediated atopic dermatitis patients. (P< 0.05) CONCLUSION: Female was more predominant in non IgE-mediated atopic dermatitis patients and IgE-mediated atopic dermatitis patients showed higher total eosinophil count and more frequency of allergic rhinitis.
