Effects of Hedysarum Polybotys Saccharide on Lipid Metabolism and Expression of Stearoyl-CoA Desaturase-1 Gene in NAFLD Rats
10.3969/j.issn.1005-5304.2014.07.014
- VernacularTitle:红芪多糖对非酒精性脂肪肝大鼠脂代谢及硬脂酰辅酶A去饱和酶1基因表达的影响
- Author:
Hongxia SHANG
;
Weiming SUN
;
Weidong CHENG
;
Yongqiang DUAN
;
Xiaofen SUN
- Publication Type:Journal Article
- Keywords:
hedysarum polybotys saccharide;
NAFLD;
lipid metabolism;
SCD-1;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(7):47-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hedysarum polybotys saccharide (HPS) on lipid metabolism and the expression of stearoyl-CoA desaturase-1(SCD-1) gene in rats with non-alcoholic fatty liver disease (NAFLD). To discuss the interfering effects of HPS on NAFLD. Methods The SD rats were randomly divided into the blank control group and the experiment group. Rats in the experiment group were fed with lipid rich food for 8 weeks to establish model and were randomly divided into model group, drug positive group and HPS group. After 8 weeks of drug intervention, the level of ALT, AST, TC, TG, HDL-c and LDL-c were measured with automatic chemistry analyzer, and expression of SCD-1 gene was measured by semi-quantitative polymerase chain reaction.Results Compared with blank control group, serum ALT, AST and TC, TG, LDL-c of model group were higher (P<0.05,P<0.01), the level of HDL-c of model group and the expression of SCD-1 gene were lower (P<0.01). Compared with model group, HPS was useful to decrease serum ALT, AST, LDL-c, TC and TG (P<0.05,P<0.01), and increase the level of HDL-c (P<0.01) and the expression of SCD-1 gene (P<0.01).ConclusionHPS had a positive effect on regulating lipid metabolic disturbance of NAFLD rats and promoting the expression of regulatory gene SCD-1.
