Relationship between Sensitization to Individual Aeroallergen, Bronchial Hyperresponsiveness and Pulmonary Function in Atopic Asthmatic Children.
- Author:
Ja Hyeong KIM
1
;
Hyo Bin KIM
;
So Yeon LEE
;
Bong Seong KIM
;
Hi Jung SEO
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Ulsan University Hospital, Ulsan, Korea.
- Publication Type:Original Article
- Keywords:
Total IgE;
Specific IgE;
Bronchial hyperresposiveness;
Pulmonary function
- MeSH:
Allergens;
Asthma;
Asthma, Exercise-Induced;
Child*;
Dermatophagoides farinae;
Dermatophagoides pteronyssinus;
Humans;
Immunoglobulin E;
Korea;
Lung;
Methacholine Chloride;
Pyroglyphidae
- From:Pediatric Allergy and Respiratory Disease
2005;15(4):399-407
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Atopy and specific immunogloguline (Ig) E to individual aeroallergen are considered a hallmark of allergic diseases, including asthma. However, the association between these parameters and lung function or bronchial hyperresponsiveness (BHR) is still controversial in previous studies. METHODS: A total of 234 atopic asthmatic children was recruited in this study. The amounts of total IgE and specific IgE were determined by employing the CAP system FEIA (Pharmacia Diagnostics, Uppsala, Sweden). Specific IgE was focused on two major inhalant allergens in Korea, Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f). To evaluate BHR, methacholine and exercise challenge tests were performed. RESULTS: In the atopic asthmatic group, total IgE correlated negatively with methacholine PC20 and positively with a maximum percentage fall in FEV1 after exercise. Specific IgE to Der f strongly correlated with a maximum percentage fall in FEV1 after exercise in atopic asthmatics, particularly exercise-induced asthma (EIA) (r=0.176, P=0.007 and r=0.199, P=0.011, respectively) and specific IgE to Der p weakly correlated with a maximum percentage fall in FEV1 after exercise only in EIA-positive children with atopic asthma (r=0.140, P=0.073), while neither of them correlated with methacholine PC20 (P> 0.05). However FEV1, FVC, and FEF25-75% were not associated with total IgE and specific IgE to Der p or Der f regardless of positivity of EIA in atopic asthmatic children. CONCLUSION: The severity of atopy and sensitization to house dust mites are significantly correlated with BHR, especially challenged by exercise but not pulmonary function in atopic asthmatic children.
