Usefulness of FEF25-75% in Methacholine Bronchial Provocation Test in Children with Asthma.
- Author:
Kyung Hwa RHEE
1
;
Ja Kyoung KIM
;
Jeong Hee KIM
;
Dae Hyun LIM
;
Byong Kwan SON
Author Information
1. Department of Pediatrics, College of Medicine, Inha University, Incheon, Korea. kimjhmd@inha.ac.kr
- Publication Type:Original Article
- Keywords:
Methacholine bronchial provocation test;
Asthma;
Forced expiratory flow between 25-75%
- MeSH:
Adolescent;
Asthma*;
Bronchial Provocation Tests*;
Child*;
Diagnosis;
Humans;
Methacholine Chloride*;
Vital Capacity
- From:Pediatric Allergy and Respiratory Disease
2005;15(4):408-414
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Although asthma is generally understood as a disease of the the small airways, FEF25-75%, an index representing peripheral small airways, is a appropriately used in the diagnosis of asthma. The objectives of this study are to assess the usefulness of FEF25-75% in children with asthma for clinical application. METHODS: Five hundred sixty two 5- to 15-year-old children with symptoms suggestive of asthma were enrolled. Methacholine bronchial provocation tests were performed and the children were divided into two groups according to their test results. RESULTS: Forced expiratory flow between 25-75 percent of vital capacity (FEF25-75%) was significantly lower in asthma group (P< 0.001). A 25 percent fall of FEF25-75% of percentage predicted value was correlated with PC20FEV1 (provacation concentration of methacholine required to reduce FEV1 by 20 percent) (r=0.601, P< 0.001). The sensitivity of PC25FEF25-75% (provocation concentration of methacholine required to reduce FEF25-75% by 25 percent) was 94.11 percent when PC20FEV1 was a point of reference. Youden's index was 0.64. CONCLUSION: FEF25-75% is an useful and sensitive index that predicts the presence or absence and the degree of bronchial hyperresponsiveness and PC25FEF25-75% should be brought into clinical application in asthmatic children.
