Effect of the volatile oil of Myristica fragrans Houtt on behaviors in despaire depressed mice
10.3760/cma.j.issn.1674-6554.2014.06.018
- VernacularTitle:肉豆蔻挥发油对行为绝望抑郁小鼠的影响
- Author:
Tingting SUN
;
Ying CUI
;
Jing WANG
;
Jingjing YANG
;
Yueyue ZHANG
;
Huawei ZHAO
;
Hengjie WANG
- Publication Type:Journal Article
- Keywords:
Volatile oil of Myristica fragrans Houtt;
Antidepressant effect;
Tail suspension tests;
Forced swimming tests;
Monoamine neurotransmitters
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(6):534-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the antidepressant effect of the volatile oil of Myristica in mice and investigate its mechanism.Methods Healthy male Kunming mice were divided into control group,fluoxetine hydrochloride group,high,medium and low dose group,and all of the mice were gavaged for 7 days.The role of antidepressant on the mice were observed with tail suspension tests and forced swimming tests.Then serotonin(5-HT),dopamine(DA) and norepinephrine (NE) in the brain of the mice were determined by enzyme-linked immunosorbent assay.Results Compared with the control group((82.60 ± 24.70)s),the medium dose group could shorten the immobility time of the tail suspension tests ((54.40± 15.87) s),and showed statistical significance (P＜ 0.05).The content of 5-HT,DA,NE in the brain of the medium group were (19.35±2.79) ng/ml,(12.16±0.71)pg/ml,(0.27±0.12) ng/ml,and control group were (14.95±4.83) ng/ml,(11.32±0.95) pg/ml,(0.20±0.11) ng/ml.Compared with the control group,the content of 5-HT of the medium dose group was increased and showed statistical significance(P＜0.05).Conclusion The volatile oil of Myristica fragrans Houtt has antidepressant effect,and may be related to raising the content of 5-HT,DA,NE in the brain of the mice,especially 5-HT.
