Expression and significance of JWA in acute myeloid leukemia

VernacularTitle:JWA在急性髓系白血病中的表达及意义
Author: Zhengmei HE ; Shandong TAO ; Yuan DENG ; Yue CHEN ; Kankan CHEN ; Banghe DING ; Liang YU
Publication Type:Journal Article
Keywords: Acute myeloid leukemia; JWA; RT-PCR; Western blot
From: The Journal of Practical Medicine 2014;(12):1912-1915
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and significance of JWA in Acute Myeloid Leukemia (AML). Methods Bone marrow mononuclear cell specimens were taken from 22 AML patients in newly diagnosis stage and complete remission stage respectively , and the JWA expression were detected at RNA and protein level. Results (1) JWA was expressed in all the samples at RNA and protein level. (2) At protein level, JWA expression was higher in the cells from newly diagnosed AML patients than in those from patients in complete remission stage (P < 0.05). (3)The complete remission rate of patients with higher expression level of JWA (87.5%) was similar to those with lower expression (83.3%). The complete remission rate of patients with higher expression level of JWA after the first course (31.25%) was lower than those with lower expression (66.7%). The early recurrence rate of patients with higher expression level of JWA (42.86%) was higher than those with lower expression (20%). Conclusion JWA may play an important role in the development and progression of AML. Increased expression of JWA may be one of the causes of refractory and relapsed AML.