Research progress of individual microRNA in malignant melanoma
10.3760/cma.j.issn.1006-9801.2014.06.020
- VernacularTitle:特异性微小RNA在恶性黑色素瘤中的研究进展
- Author:
Yan WEI
;
Kainan LI
- Publication Type:Journal Article
- Keywords:
Malignant melanoma;
microRNA;
RNA interference
- From:
Cancer Research and Clinic
2014;26(6):425-427
- CountryChina
- Language:Chinese
-
Abstract:
microRNAs (miRNAs) are small,non-coding,regulatory RNA molecules group expressed in tissues and cells in specific manner.They are well-known as playing crucial roles in cell homeostasis and carcinogenesis.In recent years,numerou of studys on individual miRNAs or miRNA patterns have been published.These study provided strong evidences that miRNAs might play important roles in malignant melanoma development and progression.Melanoma associated miRNAs often located in genomic regions with frequent gains and losses in tumours.This article focus on some individual miRNAs which involved in melanoma biology,by which may regulate many different target genes by several ways.The current therapy of this disease is also described.
