Effect of ulinastatin on serum C-reactive protein and exhaled nitric oxide in patients with bronchial asthma
10.3760/cma.j.issn.1008-6706.2014.13.023
- VernacularTitle:乌司他丁对支气管哮喘患者血清C反应蛋白和一氧化氮的影响
- Author:
Shufen SONG
;
Ping SHI
;
Tao XU
- Publication Type:Journal Article
- Keywords:
Ulinastatin;
Asthma;
C-reactive protein;
Nitric oxide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(13):1974-1976
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of ulinastatin on serum C-reactive protein (CRP) and exhaled nitric oxide(FeNO) in patients with bronchial asthma.Methods 98 patients with bronchial asthma were randomly divided into the control group (n =49 cases) and the observation group (n =49 cases).The patients in the control group were treated through the conventional treatment,while the patients in the observation group were treated through the conventional treatment plus ulinastatin.Pulmonary function,asthma symptom scores,serum CRP and FeNO were measured before and after treatment.Results FEV1％ and predicted PEF values after treatment were significantly increased (t =4.720,8.112,3.724,6.723,all P ＜ 0.05).Compared with the control group,the observation group after treatment increased more significantly (t =3.102,4.002,all P ＜ 0.05).After the treatment,the asthma symptom scores were significantly decreased (t =2.190,6.021,all P ＜ 0.05).Compared with the control group,the asthma symptom scores of the observation group significantly decreased (t =2.620,P ＜ 0.05).After treatment,FeNO and CRP were significantly decreased (t =9.124,13.076,5.772,7.064,all P ＜ 0.01).Compared with the control group,FeNO and CRP of the observation group significantly decreased (t =3.060,5.401,all P ＜ 0.05).Conclusion Ulinastatin can significantly decrease serum CRP and FeNO in patients with bronchial asthma.
