Surface Modification Technologies of Quantum Dots Based Biosensors and Their Medical Applications
10.11895/j.issn.0253-3820.140308
- VernacularTitle:量子点生物传感器中的表面修饰技术及其医学应用
- Author:
Xing LIU
;
Yang LUO
- Publication Type:Journal Article
- Keywords:
Quantum dots;
Surface modification;
Mercaptopropionc acid;
Biosensor;
Review
- From:
Chinese Journal of Analytical Chemistry
2014;(7):1061-1069
- CountryChina
- Language:Chinese
-
Abstract:
Quantum dots( QDs) as a new type of nanostructured luminescent materials have been widely used in biology, materials science, and physical optics. QD-based biosensors can rapidly and accurately detect biological macromolecules or inorganic molecules both in vivo and in vitro. The surface of QDs, prior to their biological detection applications, needed to be modified to enhance their fluorescence properties and lower their biological toxicity. Currently, the surface modification technologies mainly include polymer modification, thiol compounds modification, mercapto propionic acid compounds modification and organic groups modification. Various biosensors can be developed by adopting different modification techniques, which have been adopted to locate and track a variety of biological molecules in vivo. Although a large number of literatures have reported the biological applications of QD-based biosensors, rare systematic reviews of surface modification technologies on QDs have been witnessed. In this paper, we reviewed the surface modification technologies of QDs in biosensors and their medical applications.
