Effects of Kangshuai Yizhi Capsule on Activity of ATP in Brain Tissues and IL-6, TNF-α in Serum of Aging Rats
10.3969/j.issn.1005-5304.2014.07.012
- VernacularTitle:抗衰益智胶囊对衰老大鼠脑组织三磷酸腺苷酶活性和血清白细胞介素-6、肿瘤坏死因子-α的影响
- Author:
Shiduo ZHENG
;
Shizhang YANG
;
Yongqiang DUAN
;
Juan DU
;
Yingxia CHENG
;
Li ZHANG
;
Xiaoyi YANG
;
Jia LIU
- Publication Type:Journal Article
- Keywords:
Kangshuai Yizhi Capsule;
Na+-K+-ATP;
Ca2+-Mg2+-ATP;
IL-6;
TNF-α;
aging;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2014;(7):40-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effects of Kangshuai Yizhi Capsule on ATP in brain tissue and IL-6, TNF-α in serum of aging model rats, and explore the protective effects of the capsule on brain tissue.Methods Totally 72 rats were randomly divided into a normal group and a model group. The subacutely aging model rats were made by injectingD-gal, then aging rats were numbered and grouped by random number table into the model group, Kangshuai Yizhi high-dose group, Kangshuai Yizhi Capsule low-dose group and Naofukang group. All dose groups were received gavage by giving corresponding doses, while normal group and model group were given the same amount of saline everyday. After treated for 60 days, the activity of Na+-K+-ATP and Ca2+-Mg2+-ATP in brain tissue, and IL-6, TNF-α in serum were detected.Results Compared with normal group, Na+-K+-ATP and Ca2+-Mg2+-ATP were less active (P<0.05), but levels of IL-6 and TNF-α in model group were significantly higher, with statistical significance (P<0.05). Compared with model group, after treated with Kangshuai Yizhi Capsule, Na+-K+-ATP and Ca2+-Mg2+-ATP were more active, and IL-6 and TNF-α levels were down-regulated significantly in dose groups, with statistical significance (P<0.05). Meanwhile, Kangshuai Yizhi Capsule high-dose group showed the most obvious effect among dose groups.ConclusionKangshuai Yizhi Capsule has effects of enhancing activity of ATP in brain tissue and reducing level of proinflammatory factors.
