Relationship between single nucleotide polymorphism on FTO gene rs9939609 and obesity in children
10.3969/j.issn.1000-3606.2014.06.012
- VernacularTitle:FTO基因rs9939609位点多态性与儿童肥胖的相关性研究
- Author:
Yanming WU
;
Weiguo LI
;
Qiuming SHENG
;
Jinsheng DAI
;
Lingjun ZHANG
;
Min WU
;
Huijun GONG
- Publication Type:Journal Article
- Keywords:
obesity;
single nucleotide polymorphism;
FTOgene rs9939609;
child
- From:
Journal of Clinical Pediatrics
2014;(6):547-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of single nucleotide polymorphism (SNP) on FTO gene rs9939609 with metabolism index and obesity in children. Methods One hundred and fifty-three children (age 7-11 year) were recruited in this study, 102 of them were obese and 51 of them were overweight. One hundred and sixty children with normal body weight were recruited as control. Height, weight and biochemical indicator of liver function were measured. PCR and direct sequence were applied to detect the polymorphism of rs9939609, and the frequency of the allele was calculated. Results TT or TA/AA genotype frequency on FTOgene rs9939609 was significantly different among overweight group, obesity group and normal con-trol group (χ2=23.01, P<0.001);TA/AA genotype frequency in overweight and obesity group was significant higher than that in the control group(P<0.014). The frequencies of T and A allele in overweight group, obesity group and control group was 96.25%and 3.75%, 85.29%and 14.71%, 85.78%and 14.22%respectively. There was significant difference of allelic frequency among overweight group, obesity group and control group (χ2=21.72, P<0.001). The frequency of A allele in overweight and obe-sity group was higher than that in control group (P'<0.014). Subjects with TA/AA allele had significantly higher BMI compared with subjects with TT allele. Conclusions rs9939609 of FTO gene is associated with obesity in children, and allele A on this spot may raise BMI and leads to overweight and obesity.
