The study of efficacy of subarachnoid bupivacaine in elderly patients undergoing total hip arthroplasty in high altitude area
- VernacularTitle:高海拔地区高龄全髋关节置换术患者蛛网膜下腔注射布比卡因的药效研究
- Author:
Furong ZHANG
;
Liang HE
;
Fang WANG
;
Maiqiao YANG
;
Ruqiang ZHANG
;
Pinyi LV
- Publication Type:Journal Article
- Keywords:
Spinal anesthesia;
Bupivacaine;
Effective dose;
Total hip arthroplasty
- From:
The Journal of Clinical Anesthesiology
2014;(6):568-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ED50 and ED9 5 of subarachnoid 0.375% bupivacaine in elderly patients undergoing elective total hip arthroplasty (THA ) in high altitude area. Methods Twenty-three elderly patients,aged 73-99 years old,ASA Ⅱ or Ⅲ,selected for total hip ar-throplasty (THA)under combined spinal-epidural (CSE)anesthesia were enrolled in this study and predose of 3.0 mg,0.375% (m/v)bupivacaine administered in subarachnoid,following dosage in-creased by ratio of 0.8.Calculate the ED50 and ED9 5 of subarachnoid 0.375% bupivacaine and 95%CI.Results Twenty of 23 underwent the test completely.The ED50 (95%CI)and ED9 5 (95%CI)of 0.375% (m/v)bupivacaine were 4.81 mg (3.98-5.81 )and 7.29 mg (6.03-8.81 ),respectively. Conclusion Subarachnoid 0.375% bupivacaine (7.5 mg)can be used effectively and safely in elderly patients undergoing total hip arthroplasty in high altitudes area.
