Experimental study of embolization of rabbits’peripheral arteries using secondary level copper plated platinum coils
10.3969/j.issn.1002-1671.2014.06.036
- VernacularTitle:二级镀铜铂金微弹簧圈栓塞兔外周动脉的实验研究
- Author:
Hua JIANG
;
Jinmin PU
;
Yuyun TONG
;
Jie ZHAO
;
Lin LI
;
Yingchun LI
;
Jiaping WANG
- Publication Type:Journal Article
- Keywords:
copper;
coil;
embolizing arteries;
rabbit;
statistics
- From:
Journal of Practical Radiology
2014;(6):1035-1039
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the embolic effect on rabbits arteries using self-made copper plated platinum coil.Methods 1 7 New Zealand Big Ear Rabbits were selected.Unilateral subclavian artery or carotid artery was embolized with self-made secondary level copper plated platinum micro-coils (experimental group)through 3F-catheter.Contralateral subclavian artery or carotid artery was also embolized using secondary level platinum micro-coils (control group)as a control.The level of serum copper ions and the liver and renal function were recorded during different intervals before and after embolization.The arteriography and the tissue his-tology were observed respectively during different intervals after the embolization.Results 1 5 of 1 7 rabbits were embolized success-fully.After embolization,the level of serum copper ions increased in 2 weeks(P <0.05).However,it returned to preoperative level after 4 weeks (P >0.05).The liver and renal function was similar to that of the preoperation after 2 weeks.After embolization,an-giography showed that vascular embolization effect between two groups was not significantly different at 10 min and 30 min;howev-er,the embolization effect of experimental group was superior to that of control one (P <0.01)at 3 days and 1 week,2 weeks,4 weeks,6 weeks and 12 weeks.Pathological results showed that there were a lot of thromboses inside,outside and around the copper coil.Few thromboses appeared around platinum coil in control group.The thrombosis situation in experiment group was better than that in control one (P <0.01).However,no significant difference in inflammatory cell infiltration between two groups was found. Conclusion Self-made secondary level copper plated platinum coil has good physical property,rememorability,flexibility and con-trollability.
