Clinical features and antibiotic resistance of 54 children with invasive pneumococcal disease

VernacularTitle:儿童侵袭性肺炎链球菌病54例临床特点及耐药性分析
Author: Xiaolong ZHANG ; Zhengxiu LUO ; Zhou FU ; Jian LUO ; Enmei LIU
Publication Type:Journal Article
Keywords: invasive pneumococcal disease; clinical features; antimicrobial susceptibility; child
From: Journal of Clinical Pediatrics 2014;(6):555-558
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical features of invasive pneumococcal disease (IPD) and the antimicrobial susceptibility of invasive Streptococcus pneumoniae (Sp). Methods The clinical features of 54 children with IPD and the antimi-crobial susceptibility of 54 invasive Sp isolates were retrospectively analyzed from 2009 to 2012. Results The ratio of boys to girls in IPD was 1.35:1. Most of the children with IPD were within 2 years old. Few of the children had the onset in summer. Most of the children were diagnosed with septicemia, followed by meningitis. All of the children had middle or high fever. Forty-four children had an increased white blood cell count and 42 children had an increased C-reactive protein.β-lactam antibiotics was most frequently used in clinics, followed by vancomycin. Most of invasive Sp were resistant to penicillin. Multiple drug resis-tance was common in invasive Sp. Conclusions The incidence of IPD has seasonal difference. The clinical manifestations of IPD are diverse, with septicemia being the most common. The resistant rate to penicillin is high in invasive Sp.