Recent advances in cancer-associated circulating cell-free nucleic acids
10.3969/j.issn.1007-3969.2014.06.012
- VernacularTitle:肿瘤相关循环游离核酸的研究进展
- Author:
Xing XING
;
Yong LIU
;
Yong SUN
;
Xin ZHOU
;
Chaosu HU
- Publication Type:Journal Article
- Keywords:
Cancer;
Circulating cell-free nucleic acids;
Cancer biomarker
- From:
China Oncology
2014;(6):469-475
- CountryChina
- Language:Chinese
-
Abstract:
Circulating cell-free nucleic acids are defined as extracellular DNAs or RNAs in blood with physiological or pathological origins. Previous studies showed that the concentration of cell-free nucleic acids in the blood of cancer patients is significantly higher than in healthy people. Further studies showed that the genetic and epigenetic alterations of circulating cell-free nucleic acids are relevant to cancer development and progression, including mutation, hypermethylation, loss of heterozygosity, change of integrity, and abnormal expression of microRNAs. Detection of circulating cell-free nucleic acids shows promising potential in cancer screening, diagnosis, personalized treatment, and prognosis.
