Clinical efficacy of neoadjuvant chemotherapy combined with cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion (IHCP) after operation in advanced ovarian cancer
10.3969/j.issn.1000-8179.20140629
- VernacularTitle:新辅助化疗联合肿瘤细胞减灭术及术后腹腔热灌注化疗治疗晚期卵巢癌的疗效观察
- Author:
Xueling LOU
;
Zhanxin ZHANG
;
Xihong ZHANG
;
Yan CHENG
;
Suzhen FAN
;
Li YAO
- Publication Type:Journal Article
- Keywords:
neoadjuvant chemotherapy;
cytoreductive surgery;
advanced ovarian cancer;
intraperitoneal hyperthermic chemoperfusion
- From:
Chinese Journal of Clinical Oncology
2014;(14):930-932
- CountryChina
- Language:Chinese
-
Abstract:
Objective:We aimed to investigate the clinical efficacy of neoadjuvant chemotherapy combined with cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion (IHCP) after the operation of patients with advanced ovarian cancer. Meth-ods:Analysis of 60 patients with advanced ovarian cancer was performed at the Zhengzhou People's Hospital from April 2009 to July 2012. The patients were divided into two groups, namely, the research and control groups. The research group was treated with neoadju-vant chemotherapy combined with cytoreductive surgery and IHCP twice (cisplatin at 80 mg), and subsequently, with chemotherapy (TC/TP). The control group underwent primary cytoreductive surgery and chemotherapy (TC/TP). We compared the differences be-tween the two groups in terms of the following parameters:operation time, bleeding volume, volume of ascites, and postoperative che-motherapy. Results:The treatments in the research group were more efficient than those performed on the control group in terms of all the intraoperative indicators, and the difference between the two groups was statistically significant (P<0.05). Conclusion:Compared with conventional methods, the neoadjuvant chemotherapy combined with cytoreductive surgery and IHCP after operation was more ef-fective for patients with advanced ovarian cancer. Thus, neoadjuvant chemotherapy combined with cytoreductive surgery and IHCP af-ter operation can be applied in clinical settings.
