Ubiquitin-like proteins and hepatocellular carcinoma
10.3969/j.issn.1000-8179.20140501
- VernacularTitle:类泛素蛋白与肝癌
- Author:
Chen YAN
;
Jianghua SHAO
- Publication Type:Journal Article
- Keywords:
SUMO;
NEDD8;
ISG15;
FAT10;
hepatocellular carcinoma
- From:
Chinese Journal of Clinical Oncology
2014;(14):933-937
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-like proteins are structurally similar to ubiquitin. These proteins are processed, activated, conjugated, and re-leased from conjugates by enzymatic steps that are similar to the corresponding mechanisms for ubiquitin. Ubiquitin-like proteins regu-late a wide array of cellular processes through modification processes, such as nuclear-cytosolic transport, transcriptional regulation, protein stability, response to stress, and progression through the cell cycle. A large number of recent studies have found dysfunctional ubiquitin-like proteins in hepatocellular carcinoma. These proteins are important in tumorigenesis, cell proliferation, apoptosis, and an-giogenesis. Anticancer drug studies revealed that regulating protein modification by using ubiquitin-like proteins may alter the anti-tu-mor effects of chemotherapy and thus influence the chemosensitivity of hepatocellular carcinoma. Results indicate that ubiquitin-like proteins may become a new target for cancer therapy. The mechanism of ubiquitin-like proteins in tumorigenesis and hepatocellular car-cinoma progression is of great significance in the diagnosis and treatment of hepatocellular carcinoma.
