Alpha-Gal antigen and immunity risk control of animal-derived medical devices
10.3969/j.issn.2095-4344.2014.25.020
- VernacularTitle:α-Gal抗原与动物源性医疗器械免疫原性风险控制
- Author:
Linnan KE
;
Yu FANG
;
Yongqiang SHAN
;
Xiaoming FENG
;
Liming XU
;
Chunren WANG
- Publication Type:Journal Article
- Keywords:
antigen;
transplantation,heterologous;
review
- From:
Chinese Journal of Tissue Engineering Research
2014;(25):4051-4056
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Medical devices from animals are commonly used in clinical application. Despite their efficiency is widely accepted, their safety, especialy immunity has been concerned. OBJECTIVE:To investigate immunity risk control to medical devices from animals for safety consideration. METHODS:Using “α-Gal antigen, immunity, xenotransplantation” in Chinese and English as the key words, the first author conducted a computer search of Science direct database (www.sciencedirect.com), Wiley-Blackewel database (http://onlinelibrary.wiley.com) and Wanfang database (www.wanfang.com.cn) through screening the titles and abstracts. RESULTS AND CONCLUSION:Increasing evidence shows that, Gal α1-3Gal antigen (α-Gal antigen) is recognized as the major antigen and abundantly expressed on glycoconjugates of non-primate mammals and New World monkeys. In contrast, the α-gal epitope is not expressed on glycoconjugates of humans and Old World monkeys. Instead, they produce a very large amount of natural anti-α-Gal antibody that specificaly binds the α-gal epitope. The binding of human natural anti-α-Gal to α-gal epitopes expressed on non-primate mammal animals was expected to be unique immunological barrier in xenotransplantation. Therefore, it is important to choose raw materials, reduce or eliminate the α-Ggal epitope, establish highα-Ggal epitope detection methods with high sensitivity and good repeatability for achieving a greater safety and efficiency of medical devices from animals.
