Analysis of the therapeutic effect and prognostic factors for carcinoma of parotid gland:a retrospective report of 103 cases
10.3969/j.issn.1000-8179.20131799
- VernacularTitle:103例腮腺癌的治疗疗效和预后因素分析
- Author:
Shaoqing CHEN
;
Yu LIU
;
Junhe LI
;
Yinfang GUO
;
Zhe SUN
;
Zhenyu YOU
;
Xiaolang WANG
- Publication Type:Journal Article
- Keywords:
carcinoma of parotid gland;
post-operative radio-chemotherapy;
therapeutic effect;
prognostic analysis
- From:
Chinese Journal of Clinical Oncology
2014;(12):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Objective: This study aims to analyze the therapeutic effect and prognostic factors of carcinoma of parotid gland (CPG). Methods: Data on 103 CPG patients were retrospectively analyzed. The patients were divided into the simple surgery group (Group One) and post-operative radio-chemotherapy group (Group Two). Kaplan-Meier survival analysis, Log-rank test, and Cox re-gression analysis were employed to analyze the five-year overall survival. Chi-square test was applied to compare the local control rate and recurrence-free survival. Logistic regression analysis was used to determine the correlation between all factors and the local control rate. Results:For all patients, the five-year local control rate, five-year recurrence-free survival rate, and five-year overall survival rate were 71.49%, 69.61%, and 76.10%respectively. The five-year local control ratio (81.96%vs. 61.90%), five-year recurrence-free surviv-al (78.69%vs. 59.52%), and five-year overall survival (88.12%vs. 68.50%) were significantly improved in Group Two compared with Group One. The logistic regression analysis showed that the therapeutic method, T staging, as well as pN(+) neck and tumor differentia-tion were significantly correlated to the five-year local control rate and five-year recurrence-free survival (P<0.01). Cox regression anal-ysis showed that therapeutic method, T stage, as well as pN(+) neck and tumor differentiation were significantly correlated to the five-year overall survival (P<0.01). Conclusion:Post-operative radio-chemotherapy can improve the local control and overall survival rates. This therapeutic method is applicable to patients with T3-4 tumors, as well as pN(+) neck and middle-low differentiation.
