Clinical analysis of cancer patients with Pseudomonas aeruginosa bloodstream infections
10.3969/j.issn.1000-8179.20131815
- VernacularTitle:恶性肿瘤患者铜绿假单胞菌血流感染的临床分析
- Author:
Changsen BAI
;
Ding LI
;
Wenfang ZHANG
;
Qing ZHANG
;
Shan ZHENG
;
Peng ZHANG
- Publication Type:Journal Article
- Keywords:
cancer;
Pseudomonas aeruginosa;
bloodstream infection;
clinical analysis
- From:
Chinese Journal of Clinical Oncology
2014;(12):806-809
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze risk factors of cancer patients with Pseudomonas aeruginosa bloodstream infections and drug resistance. Methods:Clinical data of 30 cancer patients with P. aeruginosa bloodstream infection and 90 without infection who were ad-mitted in the Tianjin Medical University Cancer Institute and Hospital between January 2010 and December 2012 were retrospectively analyzed. Whonet 5.6 and SPSS19.0 software were used for statistical analysis of the data. Results:The infection group consisted of 20 male and 10 female patients with a mean age of 60.9±11.2 years. The control group consisted of 60 males and 30 females with a mean age of 51.3 ± 15.9 years. Multivariate logistic regression analysis showed that the number of hospitalization, combined with infection of other sites, and more than two types of antibiotics were independent risk factors of cancer patients with P. aeruginosa bloodstream infec-tions. P. aeruginosa showed high sensitivity(>80%) to carbapenems, ceftazidime, cefepime, aminoglycosides, and fluoroquinolones. The mortality rate of cancer patients with P. aeruginosa bloodstream infections was 60%. Conclusion:Cancer patients with P. aerugino-sa bloodstream infections have high mortality. Therefore, comprehensive prevention and control measures must be implemented in clini-cal practice to reduce P. aeruginosa bloodstream infections.
