Effect of sesamol on the hematopoietic system damage in 4 Gy 137 Csγ-Ray irradiated mice
- VernacularTitle:芝麻酚对4Gy137Csγ射线照射小鼠造血功能的影响
- Author:
Lu LU
;
Deguan LI
;
Junling ZHANG
;
Saijun FAN
;
Aimin MENG
- Publication Type:Journal Article
- Keywords:
sesamol;
irradiation;
peripheral blood
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of sesamol on the hematopoietic system in mice exposed to 4 Gy irradiation. Method Twenty C 57 BL/6 mice were randomly divided into control group, sesamol group, irradiated group and irradiated+sesamol group (n=5). Mice of control and sesamol group received sham irradiation, and the rest exposed to 4 Gy total body irradiation, dose rate 1.01 Gy/min. Mice in sesamol group and irradiated+sesamol group received a dose of 10 mg/kg sesamol administered by gavage every day for 7 days after irradiation exposure. Mice of other two groups were treated with vehicle solution. After 4 Gy irradiation 7 day, the peripheral bloods were collected. The levels of colony forming units-granulocyte-macrophage (CFU-GM) were detected. Results Compared to irradiation group, the level of WBC、cell count of BMNCs and CFU-GM significantly decreased in the irradiated mice, decreased in the irradiated mice (P<0.05). Compared to irradiation group, cell count of BMNCs and CFU-GM in the irradiated+sesamol group increased significantly (P<0.05). Conclusion Sesamol has a certain impact on the radiation-induced changes in hematopoietic system. The mechanism need to be further explored.
