Effect of apoptosis and gp 130 expression by Cap preconditioning on rats of acute myocardial injured
- VernacularTitle:卡托普利预处理对急性心肌损伤大鼠细胞凋亡及gp130表达的影响
- Author:
Ming GU
;
Xuebing JING
;
Zhaomei CHE
;
Tongku LIU
;
Yan ZHOU
- Publication Type:Journal Article
- Keywords:
captopril;
isoprenaline;
glycoprotein 130;
apoptosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):43-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of Captopril preconditioning on apoptosis and the expression of gp 130 in rats of acute myocardial injured. Method Wistar rats were randomly divided into three groups:control group, Iso group and Cap preconditioning group. Cardiomyocytes apoptosis was detected with TUNEL method. The expressions of Bcl-2 and Bax proteins in myocardium were tested by immunohistochemistry. The expression of gp 130 was tested with Western blot method. Results The index of cardiomyocytes apoptosis was decreased, the expressions of Bax proteins and gp 130 were decreased and the expression of Bcl-2 proteins was increased in Cap preconditioning group compared with Iso group (P<0.01 or P<0.05). Conclusion The expression of gp 130 could be decreased through Cap preconditioning, which can reduce the cardiomyocytes apoptosis.
