Effect of lentinan on cisplatin’s inhibition effects on cervical cancer Hela cell line
- VernacularTitle:香菇多糖对顺铂抑制Hela宫颈癌细胞增殖作用的影响
- Author:
Bei YAN
;
Shi DI
;
Gang WANG
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
lentinan;
cisplatin;
hela cell line;
cervical cancer;
apoptosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):49-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of lentinan on cisplatin’s inhibition on cervical cancer Hela cell line. Method Cervical cancer Hela cell line were divided into LEN group (only lentinan treatment), CIS group (only Cisplatin treatment), LEC group (Both Lentinan and Cisplatin treatment) and CON group (no Lentinan and Cisplatin treatment) according to their treatment methods. The differences of cell proliferation, cell cycle, PI and apoptosis were compared. Results The differences of absorbance between LEN group and CON group were not significant d1-d8 after treatment, but significant between CIS and LEC group (P<0.05). The absorbance in LEC group was significantly lower than in CIS group (P<0.05). The differences of PI and apoptosis rate in LEC and CIS group were significant (P<0.05), but not between LEN and group. The PI in LEC group was lower than in CIS group (P<0.05), while apoptosis rate was higher (P<0.05). Conclusion Lentinan could significantly promote Cisplatin’s inhibition effects on cervical cancer Hela cell line.
