Expression of miR-340 in triple negative breast cancer and their signiifcance
- VernacularTitle:miR-340在三阴性乳腺癌的表达和意义
- Author:
Shaomei FU
;
Chuyang YIN
;
Hui SONG
- Publication Type:Journal Article
- Keywords:
breast cancer;
immunohistochemistry;
miRNA
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):72-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship among the expression of miR-340 protein, occurrence, development and metastasis in triple-negative breast cancer (TNBC). Method 60 patients with breast cancer, from January 2006 to December 2012, according to the immunohistochemistry expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER-2), were divided into TNBC (33 patients) and non-TNBC (27 patients), and the breast cancer tissues (15 patients) were also selected at the same period, and the expression of miR-340 protein were detected by the immunohistochemistry. Results The positive expression of miR-340 protein was 73.33%in adjacent tissues of breast cancer, 51.52%in TNBC, 29.63%non-TNBC, the expression differences of each group were statistically significant(χ2=7.671,P<0.05). The expression of miR-340 protein in TNBC and non-TNBC patients were no significant difference in age, menopausal status and tumor size;while there were obvious correlation among clinical stage, lymph node metastasis and protein expression of miR-340 in TNBC(P<0.05). Conclusion The gene of miR-340 involves in the occurrence, development and metastasis of TNBC, they would be one of the purposes gene therapy in TNBC.
