Impact of lipids, high sensitive C-reactive protein, homocysteine and troponin I in patients with unstable angina in treatment of rosuvastatin
- VernacularTitle:瑞舒伐他汀治疗不稳定型心绞痛对血脂、高敏C反应蛋白、同型半胱氨酸和肌钙蛋白的影响
- Author:
Weifeng YAO
;
Yunfei LIU
;
Mingxi GAO
- Publication Type:Journal Article
- Keywords:
rosuvastatin;
unstable angina;
high sensitive C-reactive protein;
homocysteine;
troponin
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):97-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efifcacy of rosuvastatin in patients with unstable angina and its impact on the levels of lipids, high sensitive C-reactive protein (hs-CRP), homocysteine(Hcy) and troponin I (cTnI). Method 384 patients with unstable angina, from January 2010 to December 2012, were randomly divided into observation group and control group, each group had 192 cases, the control group received simvastatin, the observation group were gave rosuvastatin. The efficacy, and the levels of lipids, hs-CRP, Hcy and cTnI were observed after treatment. Results The total effective rate was 92.19%in observation group which was signiifcantly better than 81.25%in control group (χ2=9.044, P<0.01). Before treatment, the levels of TG , TC, LDL-C, HDL-C, Hcy, hs-CRP and cTnI showed no signiifcant difference, after treatment the levels of TG , TC and LDL-C, Hcy, hs-CRP and cTnI were signiifcantly lower than those before treatment (P<0.01), while, the levels of HDL-C signiifcantly increased than those before treatment (P<0.01), the reducing or increasing levels in observation group were more signiifcant compared with the control group (P<0.01). Conclusion Rosuvastatin treatment in unstable angina not only can reduce plasma lipid, but also reduce their inflammation, and stabilize the arterial plaque for unstable angina, it play an important role in development and prognosis.
