Correlation and clinical significance of P53 expression with epithelial-mesenchymal transition in breast cancer
10.3969/j.issn.1000-8179.20140603
- VernacularTitle:乳腺癌中P53的表达与上皮-间质转化的相关性及其临床意义
- Author:
Lili HUO
;
Hui LI
;
Feng WEI
;
Xiubao REN
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
P53;
epithelial-mesenchymal transition;
prognosis;
immunohistochemistry
- From:
Chinese Journal of Clinical Oncology
2014;(12):776-780
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to investigate the correlation and significance between the expression of P53 and epitheli-al-mesenchymal transition (EMT) in breast cancer. Methods:The expression patterns of P53, Twist, Snail, E-cadherin, N-cadherin, Vi-mentin, and Fibronectin protein were detected via immunohistochemistry in 63 cases with breast carcinoma. The correlation of P53 pro-tein with clinicopathologic features and survival of breast carcinoma, as well as the relationship between the expression of P53 and EMT, was analyzed. Results:The expression rates of P53, Twist, Snail, and EMT are 44.4%(28/63), 54.0%(34/63), 68.3%(43/63), and 41.3%(26/63), respectively. The P53 protein expression is correlated with tumor grade (P<0.05) but not with other clinicopatholog-ic features (P>0.05). The expression of P53 is also correlated with the expression of Twist and Snail, which are associated with EMT (P<0.05). Multivariate survival analysis reveals that lymph node metastasis, P53, and EMT are independent prognostic factors. Conclu-sion:The expression of P53 is correlated with tumor grade and EMT in breast cancer, which can be used as an independent prognostic factor. Therefore, P53 may be an effective target for breast cancer therapy.
