Molecular subtype and its association with prognosis in axillary lymph node-negative invasive breast cancer patients
10.3969/j.issn.1000-8179.20140283
- VernacularTitle:腋窝淋巴结阴性浸润性乳腺癌分子分型的表达及预后分析
- Author:
Xiaohui ZHANG
;
Yahli XU
;
Qiang SUN
;
Bo PAN
;
Yidong ZHOU
;
Feng MAO
;
Jinghong GUAN
;
Yan LIN
- Publication Type:Journal Article
- Keywords:
breast cancer;
subtype;
survival;
prognosis
- From:
Chinese Journal of Clinical Oncology
2014;(12):793-796
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the distribution, clinico-pathologic features, and survival status of different subtypes in axillary lymph node-negative invasive breast cancer patients. Methods:In this study, data of 183 patients were included and retrospectively ana-lyzed in terms of age distribution, clinico-pathologic features, disease-free survival (DFS), and overall survival based on different sub-types (luminal, basal-like, and HER-2 over-expression). Results:No significant differences in age, tumor size, and TNM stage was ob-served among different subtypes. The relapse rates of luminal, basal-like, and HER-2 over-expression subtypes were 3.9% (4/102), 20.4% (10/49), and 6.3% (2/32), respectively (P=0.002). The death rates of luminal, basal-like, and HER-2 over-expression subtypes were 2.0%(2/102), 6.1%(3/49), and 3.1%(1/32), respectively (P>0.05). Kaplan-Meier analysis showed that the DFS of basal-like sub-type was much lower compared with that of the luminal and HER-2 over-expression subtypes (P=0.002). Cox analysis showed that the subtype was an independent prognostic indicator (P=0.001). Conclusion:In node-negative invasive breast cancer, no significant differ-ences in age distribution, tumor size, and TNM stage was observed among different subtypes. The basal-like subtype has the worst prog-nosis. Therefore, subtype is an important independent prognostic indicator.
