The role of corn oil in type 2 diabetes rats with insulin resistance
- VernacularTitle:玉米油对2型糖尿病大鼠胰岛素抵抗的作用研究
- Author:
Yanxiang BAI
;
Xin LIU
- Publication Type:Journal Article
- Keywords:
corn oil;
type 2 diabetes;
blood glucose;
blood lipid;
insulin resistance
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):59-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of corn oil in the change of serum glucose, serum lipids and insulin in type 2 diabetes rats with insulin resistance, and attempt to find out its mechanism. Method High fat and sugar diet plus low-dose streptozotocin (STZ) was given to establish type 2 diabetes rat with insulin resistance model, the rats of which were randomly divided into normal group, model group, corn oil (0.8 mg/kg) group, rosiglitazone group. After Ig 6 weeks, fasting blood glucose (FBG), total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL), high density lipoprotein (HDL), fasting insulin (FINS), and insulin resistance index (HOMA-IR) were detected. Results Corn oil can elevate the level of HDL in diabetic rat, lower the levels of FBG, TC, TG, LDL, FINS and HOMA-IR. Conclusion Corn oil can improve insulin resistance, and decrease the serum glucose and lipid of type 2 diabetic rats.
