Progress in the studies on marine antitumor drugs ecteinascidin-743
- VernacularTitle:海洋抗肿瘤药物Ecteinascidin-743的研究新进展
- Author:
Manling MA
;
Chuanzhe KANG
;
Lijie YANG
- Publication Type:Journal Article
- Keywords:
marine antineoplastic drugs;
ecteinascidin-743;
antitumor activity
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;(1):147-149
- CountryChina
- Language:Chinese
-
Abstract:
At present the study of Marine antineoplastic drugs has already become the focus of concern around the world, Marine natural products has become an important source of clinical anti-cancer drugs. Ecteinascidin-743 from the Caribbean sea squirts Ecteinascidia turbinata extraction have been the ocean alkaloid, antitumor activity is significantly higher than the current widely used clinical antitumor drugs, inhibit a wide variety of tumor cell activity such as leukemia, ovarian cancer, soft tissue sarcoma, melanoma, cervical cancer, breast cancer, colorectal cancer, kidney cancer, prostate cancer, lung cancer and non-small cell lung cancer and other tumor cells, is the first successful application to the oceans, clinical antitumor drugs. In this paper, the drug synthesis, pharmacological and clinical research progress were reviewed.
