Preparation of Nifedipine Sustained-Release Pellet Tablets and Study of Its Release Behavior in vitro
10.3870/yydb.2014.06.028
- VernacularTitle:硝苯地平缓释微丸片的制备与体外释放度考察
- Author:
Yi ZHANG
;
Zhongwen YUAN
;
Shixia GUAN
;
Qingguo LI
;
Xiangping ZHOU
- Publication Type:Journal Article
- Keywords:
Nifedipine;
Hot melt extrusion technique;
Extrusion-spheronization technique;
Pellet tablets;
Release,in vitro
- From:
Herald of Medicine
2014;(6):790-793
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare nifedipine( NF)sustained-release pellet tablets,and study of its release behavior in vitro. Methods Soluplus was selected as a carrier to prepare solid dispersion of NF by hot melt extrusion technique( HME), and the ratio of the drug to carrier was 1:1. The samples were validated as the solid dispersion by differential scanning calorimetry(DSC). Extrusion-spheronization technique was introduced to prepare NF pellets and EudragitRS 30D was used as the coating material. The NF sustained-release tablets were prepared by direct compression of the coated pellets and suitable excipients. Results The release data in vitro proved that the drug release from the tablets was steady and complete over 24 hours. Conclusion The release of NF from sustained-release tablets is slow and steady. The method is easy to operate. The in vitro drug release pattern follows first-order kinetics.
