Effect of plasma monocyte chemotactic factor-1 protein and matrix metalloproteinase-9 of patients with coronary artery disease following percutaneous coronary interventional procedures therapy
10.3760/cma.j.issn.1008-6315.2014.07.009
- VernacularTitle:冠状动脉介入治疗对冠心病患者血浆单核细胞趋化因子1和基质金属蛋白酶9的影响
- Author:
Qin LI
;
Lijun LIU
;
Shuanli XIN
;
Chao CHANG
;
Dongyan LIU
;
Xuexia CUI
;
Shuli ZHANG
;
Yaqi LI
;
Yanjun DAI
;
Fuxian ZHANG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Percutaneous coronary interventional;
Monocyte chemotactic factor-1 protein;
Matrix metalloproteinase-9
- From:
Clinical Medicine of China
2014;(7):698-700
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of monocyte chemotactic factor-1 protein(MCP-1)and matrix metalloproteinase-9( MMP-9)of patients with coronary artery disease( CAD)following percutaneous coronary interventional( PCI). Methods Fifty patients underwent PCI procedures for CAD compromising a single coronary artery were selected as PCI group and 30 healthy individuals with normal findings by coronary angiography were selected as the control group. Plasma MCP-1 and MMP-9 were measured in all the subjects. Results The plasma MCP-1 level of patients with CAD after PCI was(19. 87 ± 5. 31)ng/ L,higher than that before operation((15. 71 ± 5. 23)ng/ L,t = 3. 95,P < 0. 01). Whereas in the control group,the MCP-1 level after coronary angiography was(13. 78 ± 5. 58)ng/ L,which was as same as that before operation (12. 42 ± 5. 39 ng/ L,P = 0. 34). Plasma MMP-9 level in the CAD patients after PCI procedures was(22. 69 ± 5. 97)mg/ L,higher than that before operation((19. 52 ± 5. 72)mg/ L,t = 2. 71,P < 0. 01). There was no significant difference in term of plasma MMP-9 level in control group befor and after operation((17. 53 ± 5. 51) mg/ L vs.(16. 69 ± 5. 42)mg/ L,P = 0. 55). Conclusion Plasma MCP-1 and MMP-9 increase in CAD patients following PCI procedures. But their roles in the vascular restenosis following the procedures need further investigation.
