The study of sustain attention of CNV in patients with subcortical ischemic vascular cognitive impairment
10.3936/j.issn.1002-0152.2014.04.001
- VernacularTitle:皮质下血管认知障碍早期注意损害的关联性负变研究
- Author:
Ling LI
;
Jian ZHENG
;
Zhujuan ZHOU
;
Xiaoyan CHEN
- Publication Type:Journal Article
- Keywords:
Vascular cognitive impairment (VCI);
Contingent negative variation(CNV);
Sustained attention
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(4):193-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of contingent negative variation(CNV) in patients with subcortical ischemic vascular cognitive impairment (SIVCI) and their relationship with continuous performance task (CPT) to establish a neuroelectrophysiological index of attention impairment in earlier period of Vascular Cognitive Impair-ment. Methods CNV was assessed in 45 SIVCI patients [30 patients with subcortical ischemic vascular cognitive impair-ment no dementia (SIVCIND ) and 15 patients with subcortical ischemic vascular dementia (SIVD )] and 15 normal con-trol (NC) by using a EB-Neuro ERP Instrument. Results ①CNV in SIVCI group were less regular compared with nor-mal control;CNV in SIVCIND group had decreased Expectancy Wave (EW) amplitudes (9.98± 4.10μV vs. 16.13±2.75μV) and EW areas (14848.10 ± 3199.16 μV · ms vs 20058.87 ± 1025.95 μV · ms) compared with normal control (P<0.05);EW amplitudes (6.25±1.52μV vs. 9.98± 4.10μV) and EW areas (8474.00±3511.94 vs. 14848.10±3199.16μV · ms) of CNV in SIVD group were significantly lower compared with SIVCIND group (P<0.05);However, there was no sig-nificant difference in CNV EW latency among three groups(F(2,57)=1.90,P>0.05);②Pearson correlation\Spearman rank correlation analysis revealed that there were significant, positive correlations between EW latency and CPT Reacting time(R=0.748, P<0.01);there were no significant relationships between CPT missing rate and EW latency(R=0.22,P>0.05)、EW amplitude(R=-0.191,P>0.05)and there were significant, negative correlations between EW area and CPT Reacting time(R=-0.718,P<0.01)、CPT missing rate(R=-0.829 ,P<0.01), EW amplitude and CPT Reacting time(R=-0.616, P<0.01). Conclusion SIVCI patients in early stage have attention deficits in sustained attention and CNV EW ar-ea may be a good neuroelectrophysiological index for sustained attention impairment .
