Effects of sinomenine on inflammatory cells of subarachnoid in a rat model of migraine
10.3936/j.issn.1002-0152.2014.04.002
- VernacularTitle:青藤碱对偏头痛模型大鼠蛛网膜下腔炎性细胞的影响
- Author:
Guobiao LUO
;
Xiaoli LIU
;
Li YANG
- Publication Type:Journal Article
- Keywords:
Migraine;
Sinomenine;
Subarachnoid;
Inflammatory cells
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(4):198-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effects of sinomenine (Sin) on inflammatory cell numbers of subarachnoid small perivascular and explore the role of anti-inflammatory of Sin in the treatment of migraine in a rat model of migraine. Methods Healthy wistar rats were randomly divided into 6 groups:normal group, model group and Sin low dose group, Sin middle dose group and Sin high dose group. The rat migraine model was established by subcutaneously administration of nitroglycerin. The brain and mater of rats were decapitated following 4 h of medical intervention. HE staining was used to stain inflammatory cells and inflammatory cells within perivascular spaces were counted under light microscope. Results Compared to normal group, the inflammatory cells (mainly lymphocyte and monocyte) within perivascular spaces were in-creased significantly in model group [(28.10 ± 2.28) vs. (1.60 ± 1.07),P<0.01)];The inflammatory cells in all three Sin groups were significantly reduced compared with model group [Sin high dose group (2.60 ± 1.43)、Sin middle dose group (5.10±1.37)、Sin low dose group (9.10±0.88) vs. (28.10±2.28),P<0.01]. Conclusions Sin can significantly reduce inflam-matory cells within perivascular spaces in the rat model of migraine, suggesting that Sin can effectively treat migraine.
