The comparative study of cognitive functions between familial and sporadic patients with first-episode schizophrenia
10.3936/j.issn.1002-0152.2014.04.006
- VernacularTitle:首发家族性和散发性精神分裂症患者认知功能的对照研究
- Author:
Mei WANG
;
Hong DENG
;
Wei DENG
;
Tao LI
;
Mingli LI
;
Na LI
;
Yin LIN
;
Hongyan REN
;
Zhaohua HUANG
;
Yinfei LI
;
Wei LEI
;
Yuanyuan HAN
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Familial;
Sporadic;
First-episode;
Cognitive function
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(4):218-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference in cognitive functions between first-episode schizophrenia pa-tients with and without family history. Methods One hundred twenty-seven patients with first-episode schizophrenia were recruited, including 40 patients with family history and 87 sporadic patients. Ninety-six matched normal subjects served as controls. Seven subscales of the Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC) were used to assess the cognitive functions of all subjects. Positive and Negative Symptom Scale (PANSS) was used to assess patients ’ symptoms. The relationship between clinical symptoms and cognitive deficits was analyzed. Results There was no signifi-cant difference in the PANSS scores between familial patients and sporadic patients [(91.51±14.07) vs. (87.23±16.37), P>0.05]. The scores of full intelligence quotient (IQ), verbal IQ and operation IQ were lower in patient groups than in con-trol group (all P<0.05). The score of operation IQ was lower in sporadic patients than in familial patients (P<0.05). The scores of PANSS (r=-0.43, P=0.01), positive symptoms (r=-0.32, P=0.04) and negative symptoms (r=-0.38, P=0.02) were negatively correlated with operation IQ, and the scores of PANSS(r=-0.41,P=0.01) and positive symptoms(r=-0.54, P<0.01) were negatively correlated with block rectification scores in sporadic patient group but not in the familial patient group (all P>0.05). Conclusion The patients with schizophrenia have significant intelligence deficits in the early stages. Cognitive deficits are associated with the disease severity in sporadic patients while are independent of clinical symptoms in familial patients.
