Association of rs2228314 polymorphism in SREBP2 with serum lipid levels and obesi-ty among children and adolescents
10.3969/j.issn.1671-167X.2014.03.004
- VernacularTitle:SREBP2基因 rs2228314多态性与儿童青少年血脂水平和肥胖的关系
- Author:
Fanghong LIU
;
Jieyun SONG
;
Jun MA
;
Xiaorui SHANG
;
Xiangrui MENG
;
Haijun WANG
- Publication Type:Journal Article
- Keywords:
Sterol regulatory element binding protein 2;
Polymorphism;
genetic;
Obesity;
Dyslipi-demias;
Child
- From:
Journal of Peking University(Health Sciences)
2014;(3):355-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between rs 2228314 polymorphism in sterol regulatory element binding protein 2 gene (SREBP2) and obesity, serum lipid levels in children and adolescents . Methods:In our study , 2 030 children and adolescents aged from 7 to 18 years participated .Anthropo-metric measurements, including height and weight, were performed.Their serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol ( HDL-C) were detected .The matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS ) was used to detect rs2228314 genotypes.Results: The GC/CC genotypes of rs2228314 polymorphisms had lower HDL-C levels than GG genotype [(0.10 ±0.35) mmol/L vs. (0.14 ±0.36) mmol/L, P=0.020].The rs2228314 polymorphism was associated with the abnormal HDL-C level under the dominant model after adjustment for study samples , sex and age ( OR=1.400, 95%CI:1.027-1.907, P=0.033).The rs2228314 polymorphism was not associated with obesity un-der the dominant model after adjustment for study samples , sex, age and HDL-C level ( OR=1.178, 95%CI: 0 .971 -1 .430 , P =0 .096 ) . Conclusion: The GC/CC genotype carriers of SREBP2 rs2228314 polymorphism have higher risk of abnormal HDL-C level than the individuals with GG geno-type among children and adolescents .
