A matched case-control study of risk factors in abdominal aortic aneurysm

Shangwei Zuo; Yingqi Wei; Feng Chen; Dafang Chen; Tao WU; Kuo Liu; Kexin Sun; Juan Juan; Jiang Xiong; Wei Guo

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A matched case-control study of risk factors in abdominal aortic aneurysm

VernacularTitle:腹主动脉瘤危险因素的病例对照研究
Author: Shangwei ZUO ; Yingqi WEI ; Feng CHEN ; Dafang CHEN ; Tao WU ; Kuo LIU ; Kexin SUN ; Juan JUAN ; Jiang XIONG ; Wei GUO
Publication Type:Journal Article
Keywords: Aortic aneurysm; abdominal; Risk factors; Case-control studies
From: Journal of Peking University(Health Sciences) 2014;(3):412-416
CountryChina
Language:Chinese
Abstract: Objective:To examine the potential influence factors of abdominal aortic aneurysm (AAA).Methods:A 1∶2 pair-matched, case-control study was conducted from July 2011 to December 2012 .A pair was composed of one AAA patient recruited from the Vascular Surgery Department , Chinese PLA General Hospital and two gender-and age-matched non-AAA subjects , one from the same hospital and the other from the community in Fangshan District in Beijing .Demographic data , medical history and the lifestyle of each subject were collected .Moreover , all the participants underwent abdominal ultra-sound or computed tomography ( CT ) and peripheral venous blood samples were obtained .Results:There were 155 case/control pairs .The multivariate conditional logistic regression model confirmed that suffering from hypertension conferred a 1.98-fold (95%CI 1.12-3.18) increased likelihood of AAA. Smoking was a strong independent risk factor of AAA , with odds ratios ( 95% confidence intervals ) of 5.23 (2.44-11.23).Dyslipidemia(OR=2.61,95%CI 1.45-4.70), a higher level of serum hs-CRP (OR=2.43,95%CI 1.37-4.31) and homocysteine (OR=2.73,95%CI 1.61-4.65) were all asso-ciated with AAA.Conclusion: Hypertension and smoking are the risk factors of AAA .Dyslipidemia, hsCRP and Hcy are associated with AAA .