Acute Toxicity Study of Water and Ethanol Extracts of Radix Millettiae Speciosae
10.3870/yydb.2014.06.007
- VernacularTitle:牛大力水提物和醇提物急性毒性实验研究
- Author:
Zengyan YANG
;
Haisong ZHOU
;
Xiangpei ZHAO
;
Jin TANG
;
Chunhui BAI
- Publication Type:Journal Article
- Keywords:
Water extract of Radix millettiae speciosae;
Ethanol extract of Radix millettiae speciosae;
Toxicity experiment,acute;
Maximum tolerated dose
- From:
Herald of Medicine
2014;(6):721-722
- CountryChina
- Language:Chinese
-
Abstract:
Methods The maximum tolerated dose( MTD)of water and ethanol extracts of Radix millettiae speciosae were measured for the safety evaluation. Results Maximal tolerated dose( MTD)of water extract was higher than 1 000 g·kg-1 ,which equaled to 110 times the dose for human adults(60 kg). MTD of ethanol extract was higher than 1 700 g·kg-1 ,which equaled to 186 times the dose for human adults(60 kg). Conclusion Radix millettiae speciosae does not have obvious toxicity,thus its routine clinical dose is safe and feasible.
