Influence of noninvasive mechanical ventilation therapy on BNP and prognosis in patients with AAMI complicated hypoxemia
10.3969/j.issn.1008-0074.2014.03.20
- VernacularTitle:无创机械通气治疗AAMI并低氧血症对BNP及预后的影响
- Author:
Chulin WANG
;
Yupeng LIN
;
Qiang WU
;
Xiaoying CHEN
;
Mingwei XU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Anoxemia;
Ventilators,mechanical;
Natriuretic peptide,brain
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(3):300-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study dynamic change of brain natriuretic peptide (BNP),left ventricular ejection fraction (LVEF)and prognosis improvement in patients with acute anterior myocardial infarction (AAMI)complicated hy-poxemia after noninvasive mechanical ventilation therapy.Methods:A total of 60 patients with AAMI complicated hypoxemia,who were hospitalized in our hospital from Mar 2011 to Oct 2013,were divided into noninvasive venti-lation group (n=28)and routine treatment group (n=32)according to number table.Dynamic change of BNP, LVEF and prognosis were observed and compared between two groups.Results:After treatment,BNP level and LVEF significantly improved in both groups (P<0.05 all),compared with routine treatment group,there was more significant reduction in BNP level [24h:(263.6±23.3)μmol/L vs.(126.2±21.9)μmol/L]and significant rise in LVEF [(40.6±13.1)% vs.(47.3±14.7)%]in noninvasive ventilation group after treatment (P<0.01 both);af-ter 30d follow-up,there were significant rise in 6min walking distance (percentage of 426~550m,59.3% vs. 75.0%),LVEF [(41.1±11.7)% vs.(49.4±12.5)%]and survival rate (90.6% vs.96.4%),and significant re-duction in rehospitalization rate (12.5% vs.7.1%)in noninvasive ventilation group,P<0.01 all.Conclusion:Ear-ly noninvasive mechanical ventilation therapy can significantly improve cardiac function,exercise tolerance and short-term prognosis in patients with acute anterior myocardial infarction complicated hypoxemia.
