Comparison of curative effect and thrombolysis time between r-tPA application and urokinase in the interventional thrombectomy and thrombolysis for acute and severe pulmonary embolism
10.3969/j.issn.1671-167X.2014.03.023
- VernacularTitle:急性高危肺栓塞介入取栓、溶栓中应用 r-tPA 与尿激酶溶栓时间及疗效比较
- Author:
Qichen FENG
;
Xuan LI
;
Guoxiang DONG
;
Jun FU
;
Changming WANG
- Publication Type:Journal Article
- Keywords:
Pulmonary embolism;
Thrombolytic therapy;
Endovascular procedures;
Tissue plasmino-gen activator;
Urokinase-type plasminogen activator
- From:
Journal of Peking University(Health Sciences)
2014;(3):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influence of r-tPA and urokinase in curative effect and thrombolysis time on patients with acute and severe pulmonary embolism after interventional thrombectomy .Methods:After reviewing and analyzing the clinical data of 19 acute and severe pulmonary embolism patients , we classified them into two groups in accordance with the application of r-tPA and urokinase to compare the changes of their heart rate , blood pressure , pulmonary arterial pressure , arterial partial pressure of oxygen and hemachrome before and after thrombolysis , as well as the thrombolysis effect time the two groups took.Results: The heart rate, blood pressure, pulmonary arterial pressure , arterial partial pressure of oxygen of the patients in both groups gained remarkable improvement after operation ( P<0 .05 );the pulmonary arterial pressure of the r-tPA patient group dropped but not significantly compared with that before operation ( P>0.05); the pulmonary arterial pressure of the urokinase patient group dropped significantly compared with that study before operation ( P<0.05 ); the hemachrome of both patient groups did not significantly drop after operation ( P>0 .05 );the thrombolysis effect time by adop-ting r-tPA was remarkably shorter than that caused in thrombolysis by adopting urokinase ( P<0 .05 ) . Conclusion: Both r-tPA and urokinase are effective in interventional thrombolysis for acute and severe pulmonary embolism .However , r-tPA could significantly shorten the time caused in thrombolysis without increasing any bleeding risk.
