Therapeutic effect of different dosages of metoprolol combined amiodarone on tachyarrhythmia
10.3969/j.issn.1008-0074.2014.03.19
- VernacularTitle:不同剂量美托洛尔联合胺碘酮治疗快速心律失常的疗效
- Author:
Peiyong ZHANG
- Publication Type:Journal Article
- Keywords:
Metoprolol;
Amiodarone;
Tachycardia
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(3):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare clinical therapeutic effects of different dosages of metoprolol combined amioda-rone on patients with tachyarrhythmia.Methods:A total of 120 patients with tachyarrhythmia were randomly divid-ed into small-dose group (n=40,received 5mg/d metoprolol),medium-dose group (n=40,received 10mg/d meto-prolol)and large-dose group (n=40,received 15mg/d metoprolol)according to number table method.Each group received combined amiodarone therapy.Clinical indexes such as acting time,sinus rhythm conversion rate and left ventricular ejection fraction (LVEF)were compared among three groups.After three-month follow up,recurrence rate of tachyarrhythmia was compared among three groups.Results:Compared with small-dose group,there was significant reduction in acting time [(7.2±1.1)h vs.(3.4±1.0)h,(2.9±0.8)h],and significant rise in sinus rhythm conversion rate (57.5% vs.85.0%,90.0%)and effective rate (62.5% vs.90.0%,95.0%)in medium-dose group and large-dose group,P<0.05 or 0.01,but there were no significant difference between medium-dose group and large-dose group (P>0.05 all).There were no significant differences in mean blood pressure and heart rate,LVEF and incidence rates of all kinds of adverse reactions among three groups (P>0.05).After three-month follow-up,recurrence rate of medium-dose group (2.5%)was significantly lower than those of large-dose group (10.0%)and small-dose group (20.0%),P<0.05. Conclusion:Medium dosage of metoprolol combined with amio-darone possesses more clinical therapeutic effect than small-dose and large-dose in patients with tachyarrhythmia;it is worth extending in clinic.
