Therapeutic effect of atorvastatin on aged patients with mild to moderate hypertension
10.3969/j.issn.1008-0074.2014.03.23
- VernacularTitle:阿托伐他汀治疗老年轻中度高血压患者的效果
- Author:
Leng HAN
;
Bo LIU
;
Donglai CAO
;
Jun HE
;
Jie NI
- Publication Type:Journal Article
- Keywords:
Atorvastatin;
Hypertension;
The aged
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(3):309-311
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore therapeutic effect of atorvastatin on aged patients with mild to moderate hyperten-sion.Methods:A total of 427 aged patients with mild to moderate hypertension treated in our hospital from Jul 2011 to Jul 2013 were randomly divided into routine treatment group (n=210)and atorvastatin group (n=217,received atorvastatin additionally based on routine treatment)according to number table.All patients were treated with a continuous 24 months.Therapeutic effect of controlling blood pressure,changes of blood pressure level and high sensitive C reactive protein (hsCRP)level and occurrence of adverse reactions during treatment were compared be-tween two groups.Results:Compared with routine treatment group,there was significant rise in total effective rate of long-term (24 months)controlling blood pressure (76.8% vs.85.9%),and significant reductions in blood pres-sure [(145.3±10.1/88.6±6.7)mmHg vs.(136.9±6.8/83.0±5.2)mmHg]and hsCRP [(2.02±0.29)mg/L vs. (1.60±0.18)mg/L]level in atorvastatin group,P<0.05 or <0.01. There was no significant difference in inci-dence rate of adverse reactions during treatment between two groups (P>0.05).Conclusion:Atorvastatin combined antihypertensive drugs can well control blood pressure and reduce inflammatory reactions,which is suitable for long term use in aged patients with hypertension.
