Therapeutic effect of recombinant human brain natriuretic peptide on cardiorenal syndrome
10.3969/j.issn.1008-0074.2014.03.30
- VernacularTitle:重组人脑利钠肽治疗心肾综合征疗效研究
- Author:
Xin LU
;
Taohong HU
;
Huili MA
;
Yurong BAI
;
Zhitao JIN
;
Weiwei LI
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Ventricular dysfunction;
Kidney failure
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(3):330-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the therapeutic effect of recombinant human brain natriuretic peptide (rhBNP)on patients with cardiorenal syndrome.Methods:The data of 75 patients,who were diagnosed as cardiorenal syndrome and hospitalized in our hospital,were retrospectively analyzed.They were randomly divided into routine treatment group (n=40,received routine treatment)and rhBNP group (n=35,received rhBNP based on routine treatment) according to number table method.The rhBNP was pumped with 0.0075μg·kg-1 ·min-1 using micropump intrave-nously,once/day,about 10h/time and 7d was regarded as a course of treatment.Changes of 24h urine volume,N terminal pro brain natriuretic peptide (NT-proBNP),glomerular filtration rate (GFR)and echocardiograph were recorded in all patients before and 7d after treatment.Results:Compared with routine treatment group after treat-ment,there were significant increase in total effective rate (62.5% vs.94.3%),24h urine volume [(785.2 ± 143.4)ml vs.(965.34±171.8)ml],GFR [(34.1±2.6)ml/min vs.(45.2±5.6)ml/min]and left ventricular e-jection fraction [(35.6±5.5)% vs.(45.9±6.8)%],and significant reduction in NT-proBNP level [(3451.1± 1314.2)pg/ml vs.(1516.43 ± 431.52)pg/ml]in rhBNP group,P<0.01 all.Conclusion:Recombinant human brain natriuretic peptide is safe,effective and can improve renal function in treating patients with cardiorenal syn-drome.
