Effects of Drag-reducing polymer derived from Aloe vera on microcirculation in burn rats
10.3969/j.issn.1006-5725.2014.10.007
- VernacularTitle:芦荟减阻剂对烧伤休克大鼠微循环的影响
- Author:
Junli ZHANG
;
Shumin CAI
;
Tao LI
;
Zhenhua ZENG
;
Youguang GAO
;
Zhongqing CHEN
- Publication Type:Journal Article
- Keywords:
Aloe vera;
Drag-reducing polymers;
Acute lung injury;
Burn Shock;
Microcirculation
- From:
The Journal of Practical Medicine
2014;(10):1537-1540
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of drag-reducing polymers on microcirculation in 40%total body surface area burn-injured rats. Methods SD rats were randomized into control group, drag-reducing polymer (DRPs) group and normal saline (NS) group (5 minutes after scald, drag-reducing polymer or saline was injected for fluid resuscitation). Wet dry weigh ratio of lung, histopathologic changes and arterial blood gas at 24 hour were respectively measured by wet dry weigh ratio method, hematoxylin-eosin (HE) staining and arterial blood gas analysis. The velocity of flow of red cell in oblique ridge and the survival time of burn-injured rats were observed. Results Compared with control group, rats in NS group exhibit significant lung injury characterized by a high W/D (P < 0.01), accumulation of a large number of neutrophils in HE stain, low partial pressure of oxygen (PO2) and high lactate (Lac) (P<0.05 or P<0.01) in arterial blood. Compared with the NS group, DRPs treatment rats exhibit significantly reduced lung injury characterized by W/D reducing (P < 0.05), the reduction of neutrophil infiltration, increased PO2, decreased Lac (P<0.05, P<0.01). In addition, DRPs treatment obviously increases the burn-induced low velocity of flow of red cell in oblique ridge (P<0.01). Moreover, the survival time of burned rats can be improved by DRPs treatment (P < 0.05). Conclusion DRPs ameliorates burn-induced acute lung injury, the mechanism may be through improving the burn-induced microcirculation disorders.
