Effects of vitamin k1, fresh frozen plasma and cryoprecipitate on coagulation index of newborns with different gestational ages
10.3969/j.issn.1006-5725.2014.10.017
- VernacularTitle:维生素K1、新鲜冰冻血浆和冷沉淀对不同出生胎龄新生儿凝血指标的影响
- Author:
Tao ZHANG
;
Jiayi LIAO
;
Feitong ZHANG
;
Xiaohua TAN
;
Qiliang CUI
- Publication Type:Journal Article
- Keywords:
Vitamin K1;
Plasma;
Cryoprecipitate;
Coagulation index;
Gestational age;
Newborn
- From:
The Journal of Practical Medicine
2014;(10):1572-1575
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Vitamin K1(Vit K1), fresh frozen plasma (plasma) andcryoprecipitate on prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen original(Fbg), thrombin time (TT) of newborns with different gestational ages. Methods The serum of 1,134 newbornsfrom The Third Affiliated Hospital of Guangzhou Medical University was collected from February 2009 to September2012. All newborns had been divided into four groups (according to the gestational age of 28-31+6 weeks, 32-33+6weeks, 34-36+6 weeks and gestational age≥37 weeks).The effect of various interventions (Vit K1, Vit K1+plasmaand Vit K1+cryoprecipitate) on PT, APTT, Fbg, and TT had been recorded. Results (1)The PT and APTT ofeach group with the interventions of Vit k1 were significantly improved (P < 0.05). (2)The PT, APTT, Fbg and TTof each group with the interventions of Vit k1 combined with plasma were significantly improved (P < 0.05). (3)ThePT, APTT and Fbg of each group with the interventions of Vit k1 combined with cryoprecipitate were significantlyimproved (P < 0.05). (4)With Vit k1 combined with plasma, PT and APTT were mostly improved and Fbg wasimproved mostly with Vit k1 combined with cryoprecipitate. Conclusion Vitamin K1, fresh frozen plasma andcryoprecipitate can effectively improvedin the coagulation index of newborns with different gestational ages.
