The effect of interferon alfα-2b on the ultrastructure and Caspase-3 levels in villus in early pregnancy with bacterial vaginal disease

VernacularTitle:干扰素α-2b对早孕合并细菌性阴道病绒毛超微结构及Caspase-3表达的影响
Author: Yuan YUAN ; Yujiao ZHANG ; Xiaodong FU
Publication Type:Journal Article
Keywords: Interferon alfα-2b; Caspase-3; Villus; Ultrastructure
From: The Journal of Practical Medicine 2014;(10):1632-1634
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of interferon alfα-2b on the ultrastructure and Caspase-3 levels in villus in early pregnancy with bacterial vaginal disease (BV). Method Early pregnant women were divided into two groups. The treated group included 25 early pregnant women with BV who chose to have an early termination and were treated with rhINFα-2b. The controling group included 30 early pregnant women without any genital tract infectious diseases. The caspase-3 levels in trophocytes were detected by immunochemistry and the ultrastructural changes were observed in villus by transmission electron microscopy. Result (1)There was no apparent difference of ultrastructural changes between the two groups. (2)There was no statistical significance of the levels of caspase-3 between the two groups (P>0.05). Conclusion The excessive apoptosis do not occur in the trophocytes when treated with INFα-2b.