Effect of combination of benazepril and beraprost sodium on urinary microalbumin, hs-CRP and TNF-αin patients with diabetic nephropathy

VernacularTitle:贝前列素钠联合贝那普利对糖尿病肾病的尿微量白蛋白和hs-CRP、TNF-α的影响
Author: Yuanbiao LUO ; Shaozhen HUANG ; Huayou LI
Publication Type:Journal Article
Keywords: Diabetic nephropathy; Benazepril; Beraprost sodium; urinary microalbumin; C-reactive protein
From: The Journal of Practical Medicine 2014;(10):1635-1637
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of the combination of benazepril and beraprost sodium on urinary microalbumin (UMA), serum high sensitivity C-reactive protein (hs-CRP) and TNF-α in patients with diabetic nephropathy(DN) in early stage. Methods From Mar. 2010 to Mar. 2013, 120 patients with early-stage DN were randomly divided into Benazepril Group, Beraprost Sodium Group and Combination Group. Each group consisted of 40 patients with medical therapy in 20-week duration. The levels of 24 h-UMA, serum hs-CRP and TNF-α were detected and compared before and after therapy. Results After treatment, the levels of 24 h-UMA, serum hs-CRP and TNF-αall decreased significantly in three groups (P<0.05) and there were lower 24 h-UMA, serum hs-CRP and TNF-αin Combination Group than those in Benazepril Group and Berapros sodium Group (P <0.05). Conclusion There is coordinating protection of combination of benazepril and beraprost sodium on diabetic nephropathy in early stage, possibly being related with the inhibiting of micro-inflammation.