Association between transforming growth factor-β1 gene polymorphism and risk of chronic hepaitis B virus infection progressing to hepatocellular carcinoma
10.3969/j.issn.1673-4130.2014.13.004
- VernacularTitle:转化生长因子-β1基因多态性与乙型肝炎病毒慢性感染发展至肝细胞癌风险的相关研究
- Author:
Zhiqiang WU
;
Yan XIONG
;
Qing FEI
;
Zhiming ZHANG
;
Shimin WU
- Publication Type:Journal Article
- Keywords:
transforming growth factor;
polymorphism,genetic;
hepatitis B virus;
carcinoma,hepatocyte
- From:
International Journal of Laboratory Medicine
2014;(13):1673-1675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the polymorphism of transforming growth factor-β1 (TGF-β1 ) gene and risk of chronic hepatitis B virus(HBV)infection progressing to hepatocellular carcinoma(HCC).Methods 120 patients with chronic HBV infection(case group)and 100 age-and sex-matched healthy individuals(healthy control group)were randomly enrolled to this study.The polymerase chain reaction-restriction fragment length polymorphism technique was adopted to detect the single nucleotide polymorphism of TGF-β1 gene(T29C),and made the comparative analysis combined with TGF-β1 mRNA level. Results The risk of HCC occurrence in the patients carrying genotype CC was decreased than that in the patients carrying geno-type TT (OR=0.317,95%CI =0.110-0.913,P =0.033;OR=284,95%CI =0.093 -0.866,P =0.027),the risk of HCC in pa-tients carrying allele C was significantly decreased compared with that in the patients carrying allele T(OR =0.570,95%CI =0.341 -0.953,P =0.032;OR=0.548,95%CI =0.320-0.936,P =0.028).In the HCC group,the patients carrying genotype CC had the lower lever of TGF-β1 mRNA.Conclusion TGF-β1 gene polymorphism(T29C)may be related to the risk of chronic HBV infection progressing to HCC.
