Effect of lamivudine combined with silibinin treatment on related blood indexes in patients with E antigen positive chronic hepatitis B
10.3969/j.issn.1673-4130.2014.13.023
- VernacularTitle:拉米夫定联合水飞蓟宾治疗对E抗原阳性的慢性乙型肝炎患者相关血液指标的影响
- Author:
Qinghui WEN
;
Fengying LI
;
Jieqing ZHAI
;
Desheng WAN
- Publication Type:Journal Article
- Keywords:
lamivudine;
silibinin;
hepatitis B virus
- From:
International Journal of Laboratory Medicine
2014;(13):1720-1721
- CountryChina
- Language:Chinese
-
Abstract:
Objective To judge the effect by understanding the change of the blood related indexes before and after the applica-tion of lamivudine combined with silibinin treatment for treating E antigen positive chronic hepatitis B to provide the basis for the individualized therapy.Methods 226 cases of E antigen positive chronic hepatitis B were selected and divided into the mild group (55 cases),moderate group (94 cases)and severe group(77 cases)according to the degree of liver function injury.The 3 groups were given oral lamivudine 100 mg once daily and oral silybinin 70mg,3 times a day.The course of treatment was 6 months;the re-lated blood indexes before and after treatment were analyzed.Results After 6 months of treatment,the recovery rate of ALT,E an-tigen negative conversion rate and HBV-DNA negative conversion rate in the mild group and the moderate group were improved in different degrees,and those in the severe group were significantly increased(P <0.05).Conclusion Lamivudine combined with sili-binin treatment can inhibit the replication of HBV-DNA more effectively,promote the recovery rate of serum ALT significantly,im-prove the E antigen negative conversion rate,especially for the patients with severe liver function injury;which improve the curative effect in the treatment of chronic hepatitis B in some extent.
