Potential roles and therapeutic applications of P2 X7 receptor in inflammation and pain
10.3969/j.issn.1001-1978.2014.07.006
- VernacularTitle:P2 X7受体在炎症和疼痛中的潜在作用及治疗应用
- Author:
Shanshan QIN
;
Bo FAN
;
Changshui XU
- Publication Type:Journal Article
- Keywords:
P2X7 receptor;
inflammatory response;
pain;
phar-macological target;
physiological roles;
therapeutic applications
- From:
Chinese Pharmacological Bulletin
2014;(7):908-911
- CountryChina
- Language:Chinese
-
Abstract:
The P2X7 receptor (P2X7 R)is a nonselective cation channel activated by extracellular ATP,and it may trigger the se-cretion of several proinflammatory substances,such as IL-1β, IL-18,TNF-α,and nitric oxide.Several preclinical studies have demonstrated that this receptor participates in inflammation and pain mechanisms,and compounds that modulate the function of this receptor show potential as new anti-inflammatory medicines. Therefore,P2X7 receptors play particularly important physiologi-cal roles and have potential clinical application in inflammation and pain,which proves it a therapeutic target for pain manage-ment.
